abstract：:Propolis is a resinous substance produced by honeybees (Apis mellifera) from the selective collection of exudates and bud secretions from several plants. In previous works, we reported the antiproliferative activity of Sonoran propolis (SP) on cancer cells; in addition we suggested the induction of apoptosis after tre...

journal_title：Chemico-biological interactions

authors： Alday E,Valencia D,Carreño AL,Picerno P,Piccinelli AL,Rastrelli L,Robles-Zepeda R,Hernandez J,Velazquez C

更新日期：2015-12-05 00:00:00

abstract：:Recombinant (r) and native butyrylcholinesterse (BChE) are potent bioscavengers of organophosphates (OPs) such as nerve agents and pesticides and are undergoing development as antidotal treatments for OP-induced toxicity. Because of the lethal properties of such agents, regulatory approval will require extensive testi...

journal_title：Chemico-biological interactions

authors： Rosenberg YJ,Adams RJ,Hernandez-Abanto S,Jiang X,Sun W,Mao L,Lee KD

更新日期：2015-12-05 00:00:00

abstract：:This study assessed the effect of the combination of anethole and ibuprofen in comparison with monotherapy by either drug alone, using two in vivo inflammatory models, namely the pleurisy and paw edema in rats. We also measured the levels of the TNF protein in plasma, and the ability of anethole to inhibit, in vitro, ...

journal_title：Chemico-biological interactions

authors： Wisniewski-Rebecca ES,Rocha BA,Wiirzler LA,Cuman RK,Velazquez-Martinez CA,Bersani-Amado CA

更新日期：2015-12-05 00:00:00

abstract：:The olefin ethylene is a ubiquitously found gas. It originates predominantly from plants, combustion processes and industrial sources. In mammals, inhaled ethylene is metabolized by cytochrome P450-dependent monooxygenases, particularly by cytochrome P450 2E1, to ethylene oxide, an epoxide that directly alkylates prot...

journal_title：Chemico-biological interactions

authors： Filser JG,Artati A,Li Q,Pütz C,Semder B,Klein D,Kessler W

更新日期：2015-11-05 00:00:00

abstract：:Fluorinated nucleoside analogues are a major class of cancer chemotherapy agents, and include the drugs 5-fluorouracil (5FU) and 5-fluoro-2'-deoxyuridine (FdUrd). The aim of this study was to examine the cellular toxicity of two novel fluorinated pyrimidine L-nucleosides that are enantiomers of D-nucleosides and may b...

journal_title：Chemico-biological interactions

authors： Murray V,Taylor CB,Gero AM,Lutze-Mann LH

更新日期：2015-10-05 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of Alzheimer's disease (AD). Our screening study indicated that the water fraction of the methanolic extract of Lycopodiella cernua (L...

journal_title：Chemico-biological interactions

authors： Hung TM,Lee JS,Chuong NN,Kim JA,Oh SH,Woo MH,Choi JS,Min BS

更新日期：2015-10-05 00:00:00

abstract：:MAP kinases are important signaling molecules regulating cell survival, proliferation and differentiation, and can be activated by cadmium stress. In this study, we demonstrate that cadmium induces phosphorylation of the yeast cell wall integrity (CWI) pathway_MAP kinase Slt2, and this cadmium-induced CWI activation i...

journal_title：Chemico-biological interactions

authors： Xiong B,Zhang L,Xu H,Yang Y,Jiang L

更新日期：2015-10-05 00:00:00

abstract：:A natural ursolic compound, 2β, 3β, 23-trihydroxy-urs-12-ene-28-olic acid (TUA) was isolated from the root of Actinidia chinensis Planch (A. chinensis Radix). Since a large number of triterpenoid compound has marked anticancer effects toward various types of cancer cell lines in vitro, this study was carried out to in...

journal_title：Chemico-biological interactions

authors： Cheng QL,Li HL,Huang ZQ,Chen YJ,Liu TS

更新日期：2015-10-05 00:00:00

abstract：:Pyrazolone based metal complexes have strong bio-activity but the anti-cancer mechanism of these derivatives is not fully understood. In recent years, Cu(II) complexes have attracted the interest of researchers increasingly because of their high antitumor activities that are usually related to DNA binding. The reactio...

journal_title：Chemico-biological interactions

authors： Vyas KM,Devkar RV,Prajapati A,Jadeja RN

更新日期：2015-10-05 00:00:00

abstract：:The hypoxia-inducible factor-1 (HIF-1) has been known to be correlated to the adaptation and proliferation of tumor cells; therefore HIF-1 has become an important target in the development of anticancer drugs. Dihydrotanshinone I (DHTS) is a phenanthrenequinone compound from Salvia miltiorrhiza Bunge, which has been u...

journal_title：Chemico-biological interactions

authors： Li J,Mi C,Ma J,Wang KS,Lee JJ,Jin X

更新日期：2015-10-05 00:00:00

abstract：:Cytochrome P450 (CYP), a superfamily of hepatic monooxygenase enzymes, catalyzes biotransformation of endogenous compounds and xenobiotics. Modification of CYPs associated with metabolic diseases and continuous consumption of diet with excessive energy levels. Tetrahydrocurcumin (THC) exhibited beneficial effects in m...

journal_title：Chemico-biological interactions

authors： Jearapong N,Chatuphonprasert W,Jarukamjorn K

更新日期：2015-09-05 00:00:00

abstract：:Thalidomide has anti-inflammatory, immunomodulatory, and anti-angiogenic properties. It has been used to treat a variety of cancers and autoimmune diseases. This study aimed to characterize anti-inflammatory activities of novel thalidomide analogs by exploring their effects on splenocytes proliferation and macrophage ...

journal_title：Chemico-biological interactions

authors： Talaat R,El-Sayed W,Agwa HS,Gamal-Eldeen AM,Moawia S,Zahran MA

更新日期：2015-08-05 00:00:00

abstract：:Keloid is an overgrowth of scar tissue that develops around a wound. The mechanisms of keloid formation and development still remain unknown, and no effective treatment is available. Searching for active natural resources may develop better prevention and treatment approaches for keloids. Aspidin PB is a natural resou...

journal_title：Chemico-biological interactions

authors： Song R,Li G,Li S

更新日期：2015-08-05 00:00:00

abstract：:In the present study, we demonstrated that calcium phosphate (CaP) nanoparticles formed in cell culture media were implicated in the process of high inorganic phosphate (Pi) mediated osteogenic differentiation of rat bone marrow stromal cells (BMSCs). Exposure of BMSCs in vitro to high Pi-containing media reduced alka...

journal_title：Chemico-biological interactions

authors： Chen XR,Bai J,Yuan SJ,Yu CX,Huang J,Zhang TL,Wang K

更新日期：2015-08-05 00:00:00

abstract：:Sulfur mustard is a highly toxic chemical warfare agent with devastating impact on intoxicated tissues. DNA cross-links are probably the most toxic DNA lesions induced in the cell by sulfur mustard. The comet assay is a very sensitive method for measuring DNA damage. In the present study using the A-549 lung cell line...

journal_title：Chemico-biological interactions

authors： Jost P,Svobodova H,Stetina R

更新日期：2015-07-25 00:00:00

abstract：:The clinical use of doxorubicin is associated with dose limiting cardiotoxicity. This is a manifestation of free radical production triggered by doxorubicin. Therefore, we evaluated the efficacy of febuxostat, a xanthine oxidase inhibitor and antioxidant, in blocking cardiotoxicity associated with doxorubicin in rats....

journal_title：Chemico-biological interactions

authors： Krishnamurthy B,Rani N,Bharti S,Golechha M,Bhatia J,Nag TC,Ray R,Arava S,Arya DS

更新日期：2015-07-25 00:00:00

abstract：:Myristicin belongs to the methylenedioxyphenyl or allyl-benzene family of compounds, which are found widely in plants of the Umbelliferae family, such as parsley and carrot. Myristicin is also the major active component in the essential oils of mace and nutmeg. However, this compound can cause adverse reactions, parti...

journal_title：Chemico-biological interactions

authors： Yang AH,He X,Chen JX,He LN,Jin CH,Wang LL,Zhang FL,An LJ

更新日期：2015-07-25 00:00:00

abstract：:Intracellular calcium (Ca(2+)i) overload induced by chronic hypoxia alters Ca(2+)i homeostasis, which plays an important role on mediating myocardial injury. We tested the hypothesis that treatment with trimetazidine (TMZ) would improve Ca(2+)i handling in hypoxic myocardial injury. Cardiomyocytes isolated from neonat...

journal_title：Chemico-biological interactions

authors： Wei J,Xu H,Shi L,Tong J,Zhang J

更新日期：2015-07-05 00:00:00

abstract：:Endometriosis is a frequent benign gynecological disease characterized by endometrial tissue outside the uterine cavity. The estimated prevalence in the general population is 6-10%, but this reaches 30-50% in women with infertility and/or pain. As ectopic tissue within the pelvic cavity provokes inflammation, endometr...

journal_title：Chemico-biological interactions

authors： Sinreih M,Anko M,Kene NH,Kocbek V,Rižner TL

更新日期：2015-06-05 00:00:00

abstract：:In humans, the aldehyde dehydrogenase superfamily consists of 19 isoenzymes which mostly catalyze the NAD(P)(+)-dependent oxidation of aldehydes. Many of these isoenzymes have overlapping substrate specificities and therefore their potential physiological functions may overlap. Thus the development of new isoenzyme-se...

journal_title：Chemico-biological interactions

authors： Buchman CD,Mahalingan KK,Hurley TD

更新日期：2015-06-05 00:00:00

abstract：:tert-Butylhydroquinone (BHQ), an antioxidant used as a food additive, exhibits an anticancer effect at low doses, but is carcinogenic in rodents at high doses. BHQ is metabolized into cytotoxic tert-butylquinone (TBQ), which is further converted to 6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one (TBEH) through 6-t...

journal_title：Chemico-biological interactions

authors： Endo S,Nishiyama A,Suyama M,Takemura M,Soda M,Chen H,Tajima K,El-Kabbani O,Bunai Y,Hara A,Matsunaga T,Ikari A

更新日期：2015-06-05 00:00:00

abstract：:The total triterpenes isolated from the fruiting bodies of Ganoderma lucidum was examined for its potential to prevent γ-radiation induced membrane damage in rat liver mitochondria and microsomes. The effects of total triterpenes on γ-radiation-induced DNA strand breaks in pBR 322 plasmid DNA in vitro and human periph...

journal_title：Chemico-biological interactions

authors： Smina TP,Maurya DK,Devasagayam TP,Janardhanan KK

更新日期：2015-05-25 00:00:00

abstract：:Cisplatin is a chemotherapy drug commonly used for the treatment of human cancers, however, drug resistance poses a major challenge to clinical application of cisplatin in cancer therapy. Recent studies have shown that chrysin, a natural flavonoid widely found in various plants and foods, demonstrated effective anti-c...

journal_title：Chemico-biological interactions

authors： Li X,Huang JM,Wang JN,Xiong XK,Yang XF,Zou F

更新日期：2015-05-05 00:00:00

abstract：:Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM) that worsens its morbidity and mortality. There is evidence that camel milk (CM) improves the glycemic control in DM but its effect on the renal complications especially the DN remains unclear. Thus the current study aimed to ch...

journal_title：Chemico-biological interactions

authors： Korish AA,Abdel Gader AG,Korashy HM,Al-Drees AM,Alhaider AA,Arafah MM

更新日期：2015-03-05 00:00:00

abstract：BACKGROUND AND AIM:This study aimed to evaluate the in vivo antitumor actions and toxicity of the dichloromethane fraction (F1B) of Moquiniastrum polymorphum subsp. floccosum (formerly Gochnatia polymorpha ssp. floccosa), composed of sesquiterpene lactones, against Walker-256 carcinosarcoma in rats. METHODS:Male Wista...

journal_title：Chemico-biological interactions

authors： Martins GG,Lívero FA,Stolf AM,Kopruszinski CM,Cardoso CC,Beltrame OC,Queiroz-Telles JE,Strapasson RL,Stefanello MÉ,Oude-Elferink R,Acco A

更新日期：2015-02-25 00:00:00

abstract：:6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. The combined treatment w...

journal_title：Chemico-biological interactions

authors： Han MA,Woo SM,Min KJ,Kim S,Park JW,Kim DE,Kim SH,Choi YH,Kwon TK

更新日期：2015-02-25 00:00:00

abstract：:Over the last few decades, food allergy (FA) has become a common disease in infants in advanced countries. However, anti-allergic medicines available in the market have no effect on FA, and consequently effective drug therapies for FA are not yet available. We have already demonstrated that mucosal mast cells play an ...

journal_title：Chemico-biological interactions

authors： Wang X,Hayashi S,Umezaki M,Yamamoto T,Kageyama-Yahara N,Kondo T,Kadowaki M

更新日期：2014-12-05 00:00:00

abstract：:Exposure to metals and metalloids including arsenic, cadmium, mercury, and nickel has been a worldwide health problem for several decades. The aim of this study was to learn how metal-induced oxidative stress triggers cell proliferation, a process of great significance for cancer. NADPH oxidase (NOX) activity and cell...

journal_title：Chemico-biological interactions

authors： Mohammadi-Bardbori A,Rannug A

更新日期：2014-12-05 00:00:00

abstract：:In a preliminary study screening anti-proliferative natural alkaloids, a very potent benzophenanthridine, chelidonine showed strong cytotoxicity in cancer cells. While several modes of death have been identified, most of anti-cancer attempts have focused on stimulation of cells to undergo apoptosis. Chelidonine seems ...

journal_title：Chemico-biological interactions

authors： Noureini SK,Esmaili H

更新日期：2014-11-05 00:00:00

abstract：:Nephrotoxicity is a major adverse effect of chromium poisoning. In the present study, we investigated the potential renoprotective effect and underlying mechanisms of carvedilol, a non-specific β-adrenergic blocker using rat model of potassium dichromate-induced nephrotoxicity. Rats were pretreated with carvedilol (10...

journal_title：Chemico-biological interactions

authors： Sahu BD,Koneru M,Bijargi SR,Kota A,Sistla R

更新日期：2014-11-05 00:00:00

abstract：:Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhib...

journal_title：Chemico-biological interactions

authors： Chen A,Qin X,Tang Y,Liu M,Wang X

更新日期：2014-10-05 00:00:00

abstract：:Pogostemonis Herba is an important Chinese medicine widely used in the treatment of gastrointestinal dysfunction. Patchouli alcohol (PA), a tricyclic sesquiterpene, is the major active constituent of Pogostemonis Herba. This study aimed to investigate the possible anti-ulcerogenic potential of PA and the underlying me...

journal_title：Chemico-biological interactions

authors： Zheng YF,Xie JH,Xu YF,Liang YZ,Mo ZZ,Jiang WW,Chen XY,Liu YH,Yu XD,Huang P,Su ZR

更新日期：2014-10-05 00:00:00

abstract：:Resveratrol, a polyphenol, found in skin of red grapes, peanuts and berries possesses anti-inflammatory, anti-carcinogenic and lipid modulation properties. Here, we demonstrate in vivo antifibrotic activity of resveratrol in a mammalian model, wherein hepatic fibrosis was induced by N'-nitrosodimethylamine (NDMA) admi...

journal_title：Chemico-biological interactions

authors： Ahmad A,Ahmad R

更新日期：2014-09-25 00:00:00

abstract：:There is growing interest in studying the toxicity and health risk of exposure to multi-pollutant mixtures found in ambient air, and the U.S. Environmental Protection Agency (EPA) is moving towards setting standards for these types of mixtures. Additionally, the Health Effects Institute's strategic plan aims to develo...

journal_title：Chemico-biological interactions

authors： Zavala J,Lichtveld K,Ebersviller S,Carson JL,Walters GW,Jaspers I,Jeffries HE,Sexton KG,Vizuete W

更新日期：2014-09-05 00:00:00

abstract：:Many studies reported that oxidative and nitrative stress might be important in the pathogenesis of diabetes and the development of its complications. In this study, we showed that α-enolase (EC 4.2.1.11, 2-phospho-d-glycerate hydrolase) was identified as the important target for oxidative and nitrative modifications ...

journal_title：Chemico-biological interactions

authors： Lu N,Li J,He Y,Tian R,Xiao Q

更新日期：2014-09-05 00:00:00

abstract：:Oxcarbazepine, a second generation antiepileptic drug belonging to the family of dibenz[b,f]azepines, is subjected to a rapid and extensive biotransformation. Oxcarbazepine demonstrates a low potential for drug interactions because its biotransformation is mainly mediated by the reduction pathway instead of oxidative ...

journal_title：Chemico-biological interactions

authors： Malátková P,Havlíková L,Wsól V

更新日期：2014-09-05 00:00:00

abstract：:Sophoricoside (SOPH) is an isoflavone glycoside isolated from the fruits of Sophora japonica. Since its first isolation in 1961, there are rare findings about the effects of SOPH on reproductive system. In the present study, the pregnant mice administrated by different doses of SOPH were used to explore the effect of ...

journal_title：Chemico-biological interactions

authors： Zhou J,Qu C,Sun Q,Wu L,Liu Y,Yang Z,Zhang J

更新日期：2014-08-05 00:00:00

abstract：:Malignant gliomas are the most common primary brain tumors, and novel ways of treating gliomas are urgently needed. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported to exhibit promising antitumor activity. Here, we evaluated the effects of UA on U87MG cells and explored the underlying molecular mechani...

journal_title：Chemico-biological interactions

authors： Shen S,Zhang Y,Zhang R,Tu X,Gong X

更新日期：2014-07-25 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs. To regulate gene expression, the AhR requires its binding partner, the aryl hydrocarbon receptor nuclear translocator (ARNT). ARNT is als...

journal_title：Chemico-biological interactions

authors： Vorrink SU,Domann FE

更新日期：2014-07-25 00:00:00

abstract：:An updated biokinetic model for human exposures to cobalt (Co) was developed based on a comprehensive set of human pharmacokinetics data collected from five male and five female volunteers who ingested ∼1 mg Co/day of a Co supplement for 3 months. Three key experimental observations from the human dosing studies were ...

journal_title：Chemico-biological interactions

authors： Unice KM,Kerger BD,Paustenbach DJ,Finley BL,Tvermoes BE

更新日期：2014-06-05 00:00:00